Thursday, July 14, 2005

JAMA -- Abstract: Contradicted and Initially Stronger Effects in Highly Cited Clinical Research, July 13, 2005, Ioannidis 294 (2): 218: "Of 49 highly cited original clinical research studies, 45 claimed that the intervention was effective. Of these, 7 (16%) were contradicted by subsequent studies, 7 others (16%) had found effects that were stronger than those of subsequent studies, 20 (44%) were replicated, and 11 (24%) remained largely unchallenged. Five of 6 highly-cited nonrandomized studies had been contradicted or had found stronger effects vs 9 of 39 randomized controlled trials (P = .008). Among randomized trials, studies with contradicted or stronger effects were smaller (P = .009) than replicated or unchallenged studies although there was no statistically significant difference in their early or overall citation impact. Matched control studies did not have a significantly different share of refuted results than highly cited studies, but they included more studies with 'negative' results. "
Abu Ghraib Tactics Were First Used at Guantanamo: "The report's findings are the strongest indication yet that the abusive practices seen in photographs at Abu Ghraib were not the invention of a small group of thrill-seeking military police officers. The report shows that they were used on Qahtani several months before the United States invaded Iraq."